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NCI Drug Dictionary


An orally available antagonist of the nociceptin receptor opioid receptor like -1 (ORL-1), with potential analgesic activity. Upon oral administration, cebranopadol binds to ORL-1 and prevents its interaction with nociceptin. This leads to a decrease of nociceptin/ORL-1-mediated signaling and interferes with the sensation of pain, which results in an analgesic effect. Nociceptin is a neuropeptide involved in the regulation of pain. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:GRT 6005
Chemical structure:spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine, 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-, (1alpha,4beta)-