NCI Drug Dictionary
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spleen tyrosine kinase inhibitor TAK-659
An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||syk inhibitor TAK659 |
syk inhibitor TAK-659
|Code names:||TAK659 |