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NCI Drug Dictionary


folate binding protein J65 peptide vaccine 
A cancer vaccine comprised of human leukocyte antigen (HLA)-A2-restricted folate binding protein (FBP) epitope J65 (9 amino acids; EIWTFSTKV), with potential immunostimulatory and antineoplastic activities. Upon intradermal injection, FBP J65 peptide vaccine may induce a specific cytotoxic T-lymphocyte (CTL) response against J65 FBP-expressing tumor cell types. FBP is a membrane-bound, tumor-associated antigen overexpressed in various tumor types, including breast, ovarian and endometrial cancers. J65 is a strongly immunogenic peptide. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:FBP J65 peptide vaccine
J65 peptide vaccine