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NCI Drug Dictionary

NCI Drug Dictionary

  

extended-release onapristone 
An extended-release (ER) formulation of onapristone, an orally bioavailable progesterone receptor (PR) antagonist, with antineoplastic activity. Onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. PR is expressed on certain cancer cell types and plays a key role in proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:ER onapristone
onapristone, extended-release formulation