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NCI Drug Dictionary

  

nivolumab 
A fully human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor PD-1 (programmed death-1 or programmed cell death-1/PCD-1) with immunopotentiation activity. Nivolumab binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands PD-L1 and PD-L2, resulting in the activation of T-cells and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and effector function through the suppression of P13k/Akt pathway activation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:anti-PD-1 human monoclonal antibody MDX-1106
Code names:BMS-936558
MDX-1106
ONO-4538
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