NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

zileuton
A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Zyflo
Abbreviation:ZLT
Chemical structures:(+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea