NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

phentolamine mesylate
The mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand names:Regitine
Vasomax
Abbreviation:PTM
Chemical structure:m-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol monomethanesulfonate