NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

dacetuzumab
A humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B lineage hematologic malignancies including multiple myeloma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Hodgkin's disease and acute lymphoblastic leukemia. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:SGN-40
Chemical structures:immunoglobulin G1, anti-(human CD40 (antigen)) (human-mouse monoclonal SGN-40 γ1-chain), disulfide with human-mouse monoclonal SGN-40 κ-chain, dimer
immunoglobulin G1, anti-[human tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40)] humanized mouse monoclonal SGN-40 [Glu353,Met355]γ1 heavy chain (217-219')-disulfide with κ light chain (223-223'':226-226'')-bisdisulfide dimer