NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

GVAX pancreatic cancer vaccine
A whole cell vaccine expressing human granulocyte macrophage-colony stimulating factor (GM-CSF) with potential antineoplastic activity. Tumor cells from prostate cancer patients are harvested and then genetically modified to secrete GM-CSF, an immune stimulatory growth factor that plays a key role in stimulating the body's immune responses against tumor cells. Because the vaccine is derived from allogeneic cells, it has demonstrated a favorable side effect profile than other approaches of delivering long-lasting GM-CSF. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:GM-CSF gene transduced allogeneic pancreatic cancer vaccine