NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- GVAX pancreatic cancer vaccine
A whole cell vaccine expressing human granulocyte macrophage-colony stimulating factor (GM-CSF) with potential antineoplastic activity. Tumor cells from prostate cancer patients are harvested and then genetically modified to secrete GM-CSF, an immune stimulatory growth factor that plays a key role in stimulating the body's immune responses against tumor cells. Because the vaccine is derived from allogeneic cells, it has demonstrated a favorable side effect profile than other approaches of delivering long-lasting GM-CSF. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: GM-CSF gene transduced allogeneic pancreatic cancer vaccine