NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

etaracizumab
A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:humanized monoclonal antibody MEDI-522
monoclonal antibody anti-alpha V beta 3 integrin MEDI-522
US brand name:Abegrin
Code name:MEDI-522
Chemical structures:immunoglobulin G1 (synthetic mouse NSO cell heavy chain variable region fragment), complex with immunoglobulin G1 (synthetic mouse NSO cell light chain variable region fragment)
immunoglobulin G1, anti-[human alphaVbeta3 (CD51/CD61, CD51/GPIIIa, CD51/platelet membrane glycoprotein IIIa, vitronectin receptor)] humanized monoclonal antibody MEDI-522 (hLM609); gamma1 heavy chain [humanized VH (Homo sapiens FR/Mus musculus CDR from clone LM609)-Homo sapiens IGHG1*03] (220-214')-disulfide with kappa light chain [humanized V-KAPPA (Homo sapiens FR/Mus musculus CDR from clone LM609)-Homo sapiens IGKC*01]; (226-226'':229-229'')-bisdisulfide dimer