NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

R(+)XK469
The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:XK469
Chemical structures:2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid
propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}-, (+ )-(R)-