NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

buthionine sulfoximine
A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthetase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:d,l-buthionine-s,r-sulfoximine
L-buthionine sulfoximine
Abbreviation:BSO
Chemical structures:2-amino-4-(S-butylsulfonimidoyl) butanoic acid
butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
S-(3-amino-3-carboxypropyl)-S-butylsulfoximine
S-(n-butyl)homocysteine sulfoximine