NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

acetylcysteine
A synthetic N-acetyl derivative of the endogenous amino acid L-cysteine, a precursor of the antioxidant enzyme glutathione. Acetylcysteine regenerates liver stores of glutathione. This agent also reduces disulfide bonds in mucoproteins, resulting in liquification of mucus. Some evidence suggests that acetylcysteine may exert an anti-apoptotic effect due to its antioxidant activity, possibly preventing cancer cell development or growth. In addition, acetylcysteine has inhibited viral stimulation by reactive oxygen intermediates, thereby producing antiviral activity in HIV patients. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:L-Alpha-acetamido-beta-mercaptopropionic Acid
N-Acetyl Cysteine
N-acetyl-3-mercaptoalanine
N-acetylcysteine
N-acetyl-L-cysteine
US brand name:Mucomyst
Foreign brand names:Airbron
Broncholysin
Brunac
Fabrol
Fluatox
Fluimucetin
Fluimucil
Fluprowit
Muco Sanigen
Mucocedyl
Mucolator
Mucolyticum
Mucosolvin
Mucret
Neo-Fluimucil
Parvolex
Respaire
Tixair
Abbreviation:NAC