NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

dichloromethotrexate
A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:dichloroamethopterin
methotrexate, dichloro
Abbreviation:DCM
Chemical structures:3',5'-dichloroamethopterin
3'-5'-dichloromethotrexate
amethopterin, 3',5'-dichloro
glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-
glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-L- (8CI)
L-glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-(9CI)
N-[3,5-dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid