NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

mitoxantrone hydrochloride
Patient Information The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:dihydroxyanthracenedione
dihydroxyanthracenedione dihydrochloride
mitoxantrone dihydrochloride
mitoxantrone HCl
mitozantrone
Foreign brand names:Mitroxone
Neotalem
Onkotrone
Pralifan
Abbreviations:DHAD
DHAQ
Code name:CL 232315
Chemical structures:1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone
dihydroxyanthracenedione