NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

recombinant interleukin-4
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-4 (IL-4). Produced primarily by activated T-cells, IL-4 binds to and activates its cell-surface receptor, stimulating the proliferation and differentiation of activated B-cells and enhancing their ability to present antigens to T-cells. As a potential immunotherapeutic agent, recombinant IL-4 also augments the effects of other cytokines on dendritic cells (DC), cytotoxic T lymphocytes (CTL), and tumor-infiltrating lymphocytes (TIL). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:B Cell Proliferating Factor
B-Cell Growth Factor
B-Cell Stimulating Factor
B-Cell Stimulatory Factor 1
Mast Cell Growth Factor-2
recombinant human IL-4
T-Cell Growth Factor 2
Abbreviations:BCGF
BCSF 1
IL-4
MCGF 2
rhIL-4