NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

idoxuridine
An iodinated analogue of deoxyuridine. Idoxuridine incorporates into DNA during the S-phase of the cell cycle, sensitizing cells to ionizing radiation by increasing DNA strand breaks. When this agent contains a radioactive isomer of iodine, the radioactive idoxuridine kills cancer cells directly after preferential incorporation into the DNA of rapidly dividing tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:5-IUdR
IDU
Iododeoxyuridine
US brand names:Dendrid
Herplex
Stoxil
Foreign brand names:Idexur
Idoxene
Idulea
Iduridin
Kerecid
Virudox
Abbreviation:IUDR
Code name:SKF 14287
Chemical structures:1-(2-deoxy-beta-D-ribofuranosyl)-5-iodouracil
2'-deoxy-5-iodouridine
5-iodo-2'-deoxyuridine