NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

idoxuridine
An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:1beta-D-2'-Deoxyribofuranosyl-5-iodouracil
2'-deoxy-5-iodouridine
5-iododeoxyuridine
5-IUdR
IDU
uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)-
uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)-
uridine, 2'-deoxy-5-iodo-
US brand names:Dendrid
Herplex
Stoxil
Foreign brand names:Idexur
Idoxene
Idulea
Iduridin
Kerecid
Virudox
Abbreviations:IDUR
IdURD
IUdR
Code name:SKF 14287
Chemical structures:1-(2-deoxy-beta-D-ribofuranosyl)-5-iodouracil
2'-deoxy-5-iodouridine
5-iodo-2'-deoxyuridine