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ketoconazole

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.

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US brand name:	Nizoral Xolegel
Foreign brand name:	Fungarest Fungoral Ketoderm Ketoisdin Orifungal M Panfungol
Abbreviation:	KCZ
Code name:	R-41400
Chemical structure:	cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
NSC code:	317629

ketoconazole

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