NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: Lysodren Foreign brand name: Lisodren Abbreviations: DDD
o,p' - DDD
Code names: CB-313
Chemical structures: 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane