NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

mitotane
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Chloditan
Chlodithane
Khloditan
Mytotan
o,p'-DDD
Ortho,para-DDD
US brand name:Lysodren
Foreign brand name:Lisodren
Abbreviations:DDD
o,p' - DDD
o,p'-DDD
Code names:CB-313
WR-13045
Chemical structures:1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane
2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane
2,4'-dichlorodiphenyldichloroethane