NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

dactinomycin
Patient Information A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:ACT-D
actinomycin C1
actinomycin D
actinomycin I1
actinomycin IV
actinomycin X 1
actinomycin-[thr-val-pro-sar-meval]
AD
dactinomycine
meractinomycin
US brand name:Cosmegen
Foreign brand name:Lyovac Cosmegen
Abbreviation:DACT
Chemical structure:2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3