NCI Drug Dictionary

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

trimethoprim-sulfamethoxazole
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:cotrimoxazole
Eslectin
insozalin
trimedin
trimezole
US brand names:Bactrim
Cotrim
Septra
Sulfamethoprim
Sulfatrim
Sulmeprim
Abbreviations:SMZ-TMP
TMP-SMX