NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

warfarin
A synthetic anticoagulant. Warfarin appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand names:Athrombin-K
Compound 42
Co-Rax
Coumadin
Panwarfin
Rodex
WARF Compound 42
Abbreviation:WARF
Chemical structures:1-(4'-hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
3-(alpha-acetonylbenzyl)-4-hydroxycoumarin
3-alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one