NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

flutamide
A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Flucinom
Flugerel
Niftolid
US brand name:Eulexin
Foreign brand names:Apimid
Chimax
Drogenil
Euflex
Eulexine
Flucinome
Fluken
Flulem
Flutabene
Flutacan
Fluta-Gry
Flutamex
Flutamin
Flutan
Flutaplex
Fugerel
Grisetin
Oncosal
Profamid
Prostacur
Prostadirex
Prostica
Prostogenat
Tafenil
Tecnoflut
Testotard
Abbreviation:FLUT
Code name:Sch 13521
Chemical structures:2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
4'-nitro-3'-trifluoromethylisobutyranilide
alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide