NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

medroxyprogesterone
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:medroxyprogesterone acetate
US brand names:Curretab
Depo-Provera
Provera
Provera Dosepak
Abbreviation:MPA
Chemical structures:(6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
17alpha-hydroxy-6alpha-methylprogesterone
6alpha-methyl-17alpha-hydroxyprogesterone
6alpha-methyl-4-pregnen-17alpha-ol-3,20-dione