NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

ifosfamide
Patient Information A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Ifomide
Iphosphamid
iphosphamide
Isoendoxan
Iso-Endoxan
isophosphamide
Naxamide
US brand names:Cyfos
Ifex
Ifosfamidum
Foreign brand names:Holoxan
Holoxane
IFO-Cell
Ifolem
Ifomida
Ifoxan
Mitoxana
Tronoxal
Abbreviations:IFF
IFO
IFX
IPP
Code names:Asta Z-4942
MJF-9325
Z-4942
Chemical structures:2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide