NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

zidovudine
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:azidothymidine
US brand name:Retrovir
Foreign brand name:Aztec
Abbreviations:AZT
ZDV
Code name:BW-A509U
Chemical structure:3'-azido-3'-deoxythymidine