NCI Drug Dictionary

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

gusperimus
A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:deoxyspergualin
Deoxyspergualin Hydrochloride
Gusperimus Trihydrochloride
Foreign brand name:Spanidin
Abbreviation:DSG
Code names:BMS-181173
BMY-42215-1
NKT-01
Chemical structures:15-deoxyspergualin hydrochloride
1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione
7-{(aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide
N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide