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flucytosine

A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
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Synonym:5-fluorocytosine
US brand name:Ancobon
Foreign brand name:Alcobon
Ancotil
Abbreviation:5-FC
Code name:Ro 2-9915
Ro-2-9915
Chemical structure:4-amino-5-fluoro-2(1H)-pyrimidinone
NSC code:103805
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