NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

stavudine
A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:didehydrodeoxythymidine
dideoxydidehydrothymidine
US brand name:Zerit
Abbreviation:d4T
Code name:BMY-27857
Chemical structures:1-(2,3-dideoxy-beta-glycero-pent-2-enofuranosyl)thymine
2',3'-didehydro-3'-deoxythymidine
3'-deoxy-2'-thymidinene