NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

theophylline
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:theophylline monohydrate
US brand names:Constant-T
Elixophyllin
LaBID
Respbid
Slo-bid
Slo-Phyllin
Somophyllin-CRT
Somophyllin-T
Theo-24
Theobid Duracap
Theochron
T-Phyl
Uniphyl
Chemical structures:1,3-dimethylxanthine monohydrate
3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrate