NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

sulindac
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:Sulindac Sulfoxide
US brand names:Aflodac
Clinoril
Foreign brand names:Algocetil
Apo-Sulin
Arthrocine
Artribid
Citireuma
Clisundac
Imbaral
Novo-Sundac
Reumofil
Reumyl
Sudac
Sulinol
Sulreuma
Abbreviation:SULIN
Code name:MK-231
Chemical structures:(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid