NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

eculizumab
A human monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Alexion
monoclonal antibody 5G1.1
monoclonal antibody anti-C5
US brand name:Soliris
Abbreviation:h5G1.1