NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

formestane
A synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:4-hydroxyandrostenedione
Foreign brand name:Lentaron
Abbreviations:4-OHA
4-OHAD
Code name:CGP-32349
Chemical structure:4-Hydroxyandrost-4-ene-3,17-dione