clodronate disodium
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.
| Synonym: | clodronate clodronic acid disodium salt dichloromethylene diphosphonate |
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| Foreign brand name: | Bonefos Clasteon Difosfonal Loron Mebonat Ossiten |
| Code name: | CL2MDP |