NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

penclomedine
A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:PEN
Code name:CRC 88-04
Chemical structure:3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl) pyridine