NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

dinutuximab
Patient Information A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Dinutuximab binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Ch14.18
MOAB Ch14.18
monoclonal antibody Ch14.18
US brand name:Unituxin
Foreign brand name:Unituxin
Abbreviation:MOAB Ch14.18