NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

denileukin diftitox
Patient Information A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:DAB(389)-interleukin-2
DAB389 interleukin-2
DAB389 interleukin-2 immunotoxin
DABIL2
US brand name:ONTAK
Abbreviations:DAB389IL2
DAB389-IL2
DAB389IL-2
Code name:LY335348