NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

rubitecan
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:9-nitrocamptothecin
9-nitro-CPT
nitrocamptothecin
US brand names:Camptogen
Orathecin
Abbreviation:9-NC
Code name:RFS 2000
Chemical structure:9-nitro-20 (S-)camptothecin