NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

leucovorin calcium
Patient Information An active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:calcium (6S)-folinate
calcium folinate
CFR
citrovorum factor
folinate calcium
folinic acid
Folinic Acid Calcium Salt Pentahydrate
Leucovorin
LV
US brand name:Wellcovorin
Foreign brand names:Adinepar
Calcifolin
Calfolex
Calinat
Cehafolin
Citofolin
Citrec
Cromatonbic Folinico
Dalisol
Disintox
Divical
Ecofol
Emovis
Flynoken A
Folaren
Folaxin
Foliben
FOLI-cell
Folidan
Folidar
Folinac
Folinoral
Folinvit
Foliplus
Folix
Imo
Lederfolat
Lederfolin
Leucosar
Rescufolin
Rescuvolin
Tonofolin
Abbreviation:CF
Acronyms:CF
CFR
LV
Chemical structures:5-formyl tetrahydrofolate
5-formyl-5,6,7,8-tetrahydrofolic acid
5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic acid
N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic acid