NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

levodopa
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym:L-dopa
US brand names:Bendopa
Dopar
Eldopar
Laradopa
Larodopa
Levopa
Foreign brand names:Cidandopa
Deadopa
Dopaflex
Dopaidan
Dopal
Dopalina
Doparkine
Doparl
Dopasol
Dopaston
Dopastral
Doprin
Eldopal
Eldopatec
Eurodopa
Ledopa
Maipedopa
Parda
Veldopa
Chemical structures:(--)-2amino-3-)3,4-dihydroxyphenyl)propanoic acid
(--)-3-(3,4-dihydroxyphenyl)-L-alanine
3-hydroxy-L-tyrosine
beta-(3,4-dihydroxyphenyl)-L-alanine