NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

isotretinoin
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:13-cis-retinoic acid
13-cis-vitamin A acid
cis-retinoic acid
isotretinoinum
neovitamin A
Neovitamin A Acid
US brand names:Accutane
Amnesteem
Cistane
Claravis
Sotret
Foreign brand names:Accure
Isotrex
Isotrexin
Oratane
Roaccutan
Roaccutane
Roacutan
Abbreviation:13-CRA
Code name:Ro 4-3780
Chemical structures:3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid