NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: streptozotocin US brand name: Zanosar Abbreviations: STZ
Code name: U-9889 Chemical structures: 2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose