NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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melphalan hydrochloride
Patient Information
A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:alanine nitrogen mustard
L-phenylalanine mustard
L-Sarcolysin
L-sarcolysin phenylalanine mustard
L-sarcolysine
phenylalanine mustard
phenylalanine nitrogen mustard
Sarcoclorin
US brand name:Alkeran
Evomela
Foreign brand name:Alkerana
Melfalan
Melphalanum
Sarkolysin
Abbreviation:L-PAM
Code name:CB-3025
WR-19813
Chemical structure:
  • 4-[bis(2-chloroethyl)amino]-L-phenylalanine, hydrochloride
  • p-di(chloroethyl)amino-L-phenylalanine, hydrochloride