NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

melphalan
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:alanine nitrogen mustard
L-phenylalanine mustard
L-Sarcolysin
L-sarcolysin phenylalanine mustard
L-sarcolysine
phenylalanine mustard
phenylalanine nitrogen mustard
US brand name:Alkeran
Foreign brand names:Alkerana
Melfalan
Melphalanum
Sarkolysin
Abbreviation:L-PAM
Code names:CB-3025
WR-19813
Chemical structures:4-[bis(2-chloroethyl)amino]-L-phenylalanine
p-di(chloroethyl)amino-L-phenylalanine