NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

chlorambucil
Patient Information An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:chlorambucilum
chloraminophen
Chlorbutin
chlorbutine
chlorbutinum
chloroambucil
chlorobutin
chlorobutine
Leukersan
Leukoran
Lympholysin
phenylbutyric acid nitrogen mustard
US brand names:Ambochlorin
Amboclorin
Leukeran
Linfolizin
Foreign brand names:Alti-chlorambucil
Chloraminophene
Linfolysin
Abbreviations:CHL
CLB
Code names:CB-1348
WR-139013
Chemical structures:4-[bis(2-chloroethyl)amino]benzenebutanoic acid
4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid
benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)
butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)
gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid
gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid
N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid
p-(N, N-di-2-chloroethyl)aminophenyl butyric acid
para-N,N-di(b-chloroethyl)aminophenylbutyric acid
p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid