NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

fluorouracil
Patient Information An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:5-fluorouracil
5-Fluracil
Fluoro Uracil
Fluouracil
FU
US brand names:Adrucil
Efudex
Fluoroplex
Foreign brand names:AccuSite
Actino-Hermal
Arumel
Cytosafe
Efurix
Fiverocil
Flurablastin
Fluracedyl
Fluracil
Fluril
Fluroblastin
Flurox
Ribofluor
Timazin
Abbreviation:5-FU
Code name:Ro-2-9757
Chemical structures:2,4-Dioxo-5-fluoropyrimidine
5-Fluoro-2,4(1H,3H)-pyrimidinedione