NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

fluorouracil injection
Patient Information
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:5-fluorouracil injection
5-Fluracil
fluouracil
Fluracil
Foreign brand name:AccuSite
Flurablastin
Fluracedyl
Fluril
Fluroblastin
Ribofluor
Abbreviation:5-FU injection
FU
Code name:Ro-2-9757
Chemical structure:
  • 2,4-dioxo-5-fluoropyrimidine
  • 5-fluoro-2,4(1H,3H)-pyrimidinedione