NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

genistein
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:CI 75610
Genestein
genisteol
genisterin
prunetol
sophoricol
Chemical structures:4',5,7-trihydroxyisoflavone
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one