NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

liposomal cisplatin
A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids. Liposomal cisplatin consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Cisplatin, Liposomal
STEALTH Cisplatin
STEALTH Liposomal Cisplatin
STEALTH Liposomal Encapsulated Cisplatin
STEALTH Liposome Cisplatin
Code names:SPI-077