NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

lucatumumab
A monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:monoclonal antibody CHIR-12.12
Abbreviation:MOAB CHIR-12.12
Code names:CHIR-12.12
HCD-122
Chemical structure:immunoglobulin G1, anti-(human CD40 (antigen)) (human monoclonal CHIR-12.12 heavy chain), disulfide with human monoclonal CHIR-12.12 light chain, dimer