prednisolone
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations.
| Synonym: | delta(1)hydrocortisone delta1-dehydro-hydrocortisone deltahydrocortisone metacortandralone |
|---|---|
| US brand name: | Cortalone Delta-Cortef Hydeltra Hydeltrasol Meti-derm Prelone |
| Foreign brand name: | Adnisolone Aprednislon Capsoid Cortisolone Dacortin H Decaprednil Decortin H Delta- Cortef Delta-Diona Delta-Phoricol Deltacortril Deltasolone Deltidrosol Dhasolone Di-Adreson-F Dontisolon D Estilsona Fisopred Frisolona Gupisone Hostacortin H Klismacort Kuhlprednon Lenisolone Lepi-Cortinolo Linola-H N Linola-H-Fett N Longiprednil Meticortelone Opredsone Panafcortelone Precortisyl Pred-Clysma Predeltilone Predni-Coelin Predni-Helvacort Prednicortelone Prenilone |
| Abbreviation: | PRDL |
| Chemical structure: | (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 1,2-dehydrohydrocortisone |
| IND number: | 2537 |
| NSC code: | 9900 |