NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

BL22 immunotoxin
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonyms:Anti-CD22 Recombinant Immunotoxin BL22
BL22
BL22 Immunotoxin [RFB4(dsFv) - PE38
RFB4(dsFv)-PE38 immunotoxin
Abbreviation:BL22
Code name:CAT-3888